Annual report pursuant to Section 13 and 15(d)

Summary of Significant Accounting Policies - Additional Information (Details)

v3.22.0.1
Summary of Significant Accounting Policies - Additional Information (Details) - USD ($)
1 Months Ended 12 Months Ended
Nov. 16, 2020
Dec. 31, 2020
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2018
Sep. 05, 2018
Summary of Significant Accounting Policies [Line Items]            
Depreciation, Depletion and Amortization     $ 87,000 $ 201,000    
Cash and Cash Equivalents, at Carrying Value.   $ 6,227,000 $ 67,325,000 6,227,000    
Equity Method Investment, Ownership Percentage     83.00%      
Accrued Liabilities     $ 700,000      
Prepaid Expense   500,000 500,000 500,000    
Effect of Warrant exercise price adjustment   900,000 0 880,000    
Net Loss Attributable to Non-controlling Interest     $ (1,000) $ (73,000)    
Preferred Stock Shares Converted 1.38   3,973 3,665    
Right of use asset   279,000 $ 1,383,000 $ 279,000    
Operating Lease Liability   287,000 124,000 287,000    
Preferred stock price adjustment     7,402,000 $ 0    
Series A and Series B Preferred Stock [Member]            
Summary of Significant Accounting Policies [Line Items]            
Net Loss Attributable to Non-controlling Interest     100,000      
Series B Preferred Stock [Member]            
Summary of Significant Accounting Policies [Line Items]            
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount       3,454,783    
Preferred stock accrued dividends     1,496,000 $ 1,380,000    
Accretion of preferred discount $ 900,000 1,400,000 1,500,000 $ 1,400,000    
Series A Preferred Stock [Member]            
Summary of Significant Accounting Policies [Line Items]            
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount       678,258    
Preferred stock accrued dividends     24,000 $ 254,000    
Effect of Warrant exercise price adjustment       1,000,000.0    
Accretion of Preferred Stock Deemed Dividend       300,000    
Accretion of preferred discount     100,000   $ 6,900,000  
Preferred stock price adjustment     $ 7,402,000 $ 0    
Warrant [Member]            
Summary of Significant Accounting Policies [Line Items]            
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount     6,344,966 18,000,713    
Options [Member]            
Summary of Significant Accounting Policies [Line Items]            
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount     6,255,275 3,997,418    
Money Market Accounts [Member]            
Summary of Significant Accounting Policies [Line Items]            
Cash and Cash Equivalents, at Carrying Value.   $ 114,000,000 $ 193,000,000 $ 114,000,000    
SYN Biomics [Member]            
Summary of Significant Accounting Policies [Line Items]            
Equity Method Investment, Ownership Percentage     100.00%     88.50%
Noncontrolling Interest, Ownership Percentage by Parent           11.50%
Net Loss Attributable to Non-controlling Interest       $ 2,800,000