Annual report pursuant to Section 13 and 15(d)

License, Collaborative and Employment Agreements and Commitments - Additional Information (Details)

v3.19.3.a.u2
License, Collaborative and Employment Agreements and Commitments - Additional Information (Details) - USD ($)
1 Months Ended 12 Months Ended
Dec. 05, 2019
Dec. 04, 2019
Aug. 07, 2019
Sep. 05, 2018
Sep. 05, 2018
Dec. 04, 2017
Aug. 31, 2015
Aug. 29, 2015
Aug. 10, 2015
Dec. 05, 2013
Oct. 05, 2012
Dec. 06, 2018
Jan. 17, 2017
Aug. 31, 2015
Aug. 29, 2015
Dec. 19, 2012
Dec. 19, 2012
Nov. 28, 2012
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2015
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Line of Credit Facility, Periodic Payment, Interest                                     $ 381,150    
Salary and Wage, Officer, Excluding Cost of Good and Service Sold                                         $ 385,000
Payments for Other Fees           $ 4,500,000                              
Payments to Acquire in Process Research and Development       $ 441,000                                  
Exchange percentage of unregistered common stock                                     50.00%    
Proceeds from (Repurchase of) Equity         $ 3,000,000                           $ 3,000,000    
Options To Be Received Common Stock Shares                                     2,000,000    
Fair Value Of Shares Issued       $ 285,000                                  
Operating Lease, Cost                                     $ 201,000 $ 201,000  
Operating Lease, Payments                                     300,000    
Non Cash Addition of Right of Use Assets                                     $ 537,000    
Operating Lease, Weighted Average Discount Rate, Percent                                     9.90%    
Licensing Agreements [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Annual payments due under license agreement                               $ 50,000          
Final payment due under license agreement                               25,000          
Payments for Other Fees                   $ 150,000                      
Stock Issued During Period, Shares, New Issues                   9,569                      
Patents [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Payments for Other Fees                   $ 220,000                      
Riley Employment Agreement [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Salary and Wage, Officer, Excluding Cost of Good and Service Sold           $ 200,000                              
Deferred Compensation Arrangement with Individual, Compensation Expense                         $ 550,000           $ 5,397    
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage                         75.00%                
Shallcross Employment Agreement [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Cash Payment for License Agreement                                     8,000    
Deferred Compensation Arrangement with Individual, Compensation Expense   $ 565,000                   $ 550,000                  
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage                       75.00%                  
Jeffrey Riley [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage                                         75.00%
Steven A. Shallcross [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Shares Issued, Price Per Share   $ 0.418                                      
Cost of Living Adjustments Percentage 3.00%                                        
Deferred Compensation Arrangement with Individual, Compensation Expense $ 565,000                                        
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage   75.00%                                      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross   450,000                                      
Intrexon [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Stock Issued During Period, Shares, Acquisitions                     101,492                    
Shares Issued, Price Per Share                     $ 0.001                    
Milestone Payment upon First Dosing                 $ 2,000,000                   $ 2,000,000    
Prev Abr Llc [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Additional Cash Payment for License Agreement                                   $ 235,000      
Unregistered Shares Issued to License Agreement                                   17,858      
Additional Consideration Payable                                   50% in cash and 50% in our stock      
Options To Be Received Common Stock Shares                                         18,724
Phase I Clinical Trials [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Milestone Payment                                 $ 50,000        
Phase III Clinical Trials [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Milestone Payment                                 100,000        
NDA Submission In US [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Milestone Payment                                 250,000        
European Medicines Agency Approval [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Milestone Payment                                 100,000        
Regulatory Approval In Asian Country [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Milestone Payment                                 100,000        
PKU ECC [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Shares, Issued                 26,786                        
Stock Issued                 $ 3,000,000                        
Stock Purchase Agreement [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Conversion of Stock, Shares Converted                             38,572            
Conversion of Stock, Shares Issued             38,572 38,572           38,572              
Clinical Trial Agreement [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Estimated Research Costs     $ 3,200,000                                    
First Year [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Research Agreement Fixed Fee                               303,287 303,287        
Second Year [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Research Agreement Fixed Fee                               316,438 316,438        
Third Year [Member]                                          
License, Collaborative and Employment Agreements and Commitments [Line Items]                                          
Research Agreement Fixed Fee                               $ 328,758 $ 328,758