Annual report pursuant to Section 13 and 15(d)

License, Collaborative and Employment Agreements and Commitments (Details Textual)

v3.8.0.1
License, Collaborative and Employment Agreements and Commitments (Details Textual) - USD ($)
1 Months Ended 12 Months Ended
Dec. 04, 2017
Dec. 04, 2015
Aug. 10, 2015
Dec. 05, 2013
Oct. 05, 2012
Nov. 30, 2017
Jan. 17, 2017
Aug. 31, 2015
Aug. 29, 2015
Apr. 28, 2015
Apr. 17, 2014
Dec. 19, 2012
Nov. 28, 2012
Feb. 29, 2012
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2012
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Line of Credit Facility, Periodic Payment, Interest                             $ 381,150      
Research and Development Expense                             18,784,000 $ 29,109,000 $ 32,906,000  
Operating Leases, Rent Expense                             199,000 145,000 108,000  
Officers Compensation                     $ 385,000     $ 348,000     385,000  
Operating Leases, Future Minimum Payments Due, Next Twelve Months                             $ 292,000      
Payments for Fees           $ 5,500,000                        
Payments to Acquire in Process Research and Development                               643,000 $ 424,000  
Exchange percentage of unregistered common stock                             50.00%      
Proceeds from (Repurchase of) Equity, Total                             $ 3,000,000 3,000,000    
Options To Be Received Common Stock Shares                             2,000,000      
Operating Annual Lease Payments                               $ 285,843    
Stock Purchase Agreement [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Conversion of Stock, Shares Converted                 1,350,000                  
Conversion of Stock, Shares Issued               1,350,000 1,350,000                  
Channel Collaboration Agreement [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Shares, Issued     937,500                              
Stock Issued     $ 3,000,000                              
Mark Pimentel [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Common stock Outstanding Percentage                             0.00%      
Licensing Agreements [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Payments for Fees       $ 150,000                            
Stock Issued During Period, Shares, New Issues       334,911                            
Patents [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Payments for Fees       $ 220,000                            
Riley Employment Agreement [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Officers Compensation $ 200,000                                  
Deferred Compensation Arrangement with Individual, Compensation Expense   $ 550,000         $ 385,000               $ 188,927      
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage   75.00%         75.00%                      
Shallcross Employment Agreement [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Cash Payment for License Agreement                             8,000      
Deferred Compensation Arrangement with Individual, Compensation Expense                   $ 315,000                
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage                   75.00%                
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross                   900,000                
Jeffrey Riley [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value                           1,700,000        
Officers Compensation                           $ 750,000        
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage                                 75.00%  
Steven A. Shallcross [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value                                 $ 1,900,000  
Deferred Compensation Arrangement with Individual, Compensation Expense                             346,500      
Intrexon [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Research and Development Expense                                   $ 7,800,000
Milestone Payment     27,000,000                              
Stock Issued During Period, Shares, Acquisitions         3,552,210                          
Shares Issued, Price Per Share         $ 0.001                          
Milestone Payment upon First Dosing     $ 2,000,000                       2,000,000      
Intrexon [Member] | Minimum [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Royalty Revenue, Total                             100,000,000      
Intrexon [Member] | Maximum [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Royalty Revenue, Total                             $ 750,000,000      
Prev Abr Llc [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Additional Cash Payment for License Agreement                         $ 235,000          
Unregistered Shares Issued to License Agreement                         625,000          
Additional Consideration Payable                         50% in cash and 50% in our stock          
Options To Be Received Common Stock Shares                                 655,321  
Cedars-Sinai Medical Center [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Common stock Outstanding Percentage                             0.00%      
Office Space In Ann Arbor [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Operating Leases, Future Minimum Payments Due, Next Twelve Months                                   40,000
Office Space In Rockville [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Operating Annual Lease Payments                                   $ 142,172
December 31, 2014 [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Operating Leases, Future Minimum Payments Due, Next Twelve Months                       $ 50,000            
December 31, 2015 [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Operating Leases, Future Minimum Payments Due, Next Twelve Months                       25,000            
Phase I Clinical Trials [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Milestone Payment                       50,000            
Phase III Clinical Trials [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Milestone Payment                       100,000            
NDA Submission In US [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Milestone Payment                       250,000     $ 2,500,000      
European Medicines Agency Approval [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Milestone Payment                       100,000            
Regulatory Approval In Asian Country [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Milestone Payment                       100,000            
First Year [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Research Agreement Fixed Fee                       303,287            
Second Year [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Research Agreement Fixed Fee                       316,438            
Third Year [Member]                                    
License, Collaborative and Employment Agreements and Commitments [Line Items]                                    
Research Agreement Fixed Fee                       $ 328,758