9605 Medical Center Drive, Suite 270
Rockville, Maryland 20850



  August 20, 2018  



United States Securities
and Exchange Commission
Division of Corporation Finance

Office of Healthcare & Insurance

100 F Street, NE

Washington, D.C. 20549

Attention:Ms. Irene Paik

Ms. Christine Westbrook


Re:Synthetic Biologics, Inc.

Registration Statement on Form S-3

Filed August 1, 2018

File No. 333-226500


Dear Mss. Paik and Westbrook:


Synthetic Biologics, Inc. (the “Company”) hereby requests acceleration of the effective date of the above-referenced Registration Statement on Form S-3 so that it may become effective at 5:00 p.m. (New York City Time) on Wednesday, August 22, 2018, or as soon thereafter as reasonably practicable.


The Company hereby authorizes its legal counsel, Leslie Marlow and/or Patrick Egan of Gracin & Marlow, LLP, to orally modify or withdraw this request for acceleration. Please contact Ms. Marlow at (516) 496-2223 or (212) 907-6457, or Mr. Egan at (914) 557-5574 with any questions you may have concerning this request, and please notify either of them when this request for acceleration has been granted.


  Very truly yours,  
  By:  /s/ Steven A. Shallcross  
Steven A. Shallcross
Interim Chief Executive Officer and Chief Financial Officer