Annual report pursuant to Section 13 and 15(d)

License, Collaborative and Employment Agreements and Commitments (Details Textual)

v3.6.0.2
License, Collaborative and Employment Agreements and Commitments (Details Textual) - USD ($)
1 Months Ended 10 Months Ended 12 Months Ended
Dec. 04, 2015
Aug. 10, 2015
Dec. 31, 2016
Aug. 31, 2015
Aug. 29, 2015
Aug. 10, 2015
Apr. 28, 2015
Mar. 18, 2015
Feb. 29, 2012
Dec. 31, 2016
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2012
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Research and Development Expense                     $ 29,109,000 $ 32,906,000 $ 14,489,000  
Operating Leases, Rent Expense                   $ 285,843 145,000 108,000 77,000  
Operating Leases, Future Minimum Payments Due, Next Twelve Months     $ 204,000             204,000 204,000      
Prepaid Expense and Other Assets, Current     $ 2,515,000             $ 2,515,000 2,515,000 9,519,000    
Payments to Acquire in Process Research and Development                     $ 643,000 424,000 $ 293,000  
Exchange percentage of unregistered common stock     50.00%             50.00% 50.00%      
Proceeds from (Repurchase of) Equity, Total                     $ 3,000,000      
Stock Purchase Agreement [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Conversion of Stock, Shares Converted         1,350,000                  
Conversion of Stock, Shares Issued       1,350,000 1,350,000                  
Channel Collaboration Agreement [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Shares, Issued   937,500       937,500                
Stock Issued   $ 3,000,000       $ 3,000,000                
Mark Pimentel [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Common stock Outstanding Percentage     8.50%             8.50% 8.50%      
Licensing Agreements [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Payments for Fees                     $ 150,000      
Stock Issued During Period, Shares, New Issues                     334,911      
Patents [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Payments for Fees                     $ 220,000      
Riley Employment Agreement [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Deferred Compensation Arrangement with Individual, Compensation Expense $ 550,000             $ 385,000            
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage               75.00%            
Shallcross Employment Agreement [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Deferred Compensation Arrangement with Individual, Maximum Contractual Term             2 years              
Jeffrey Riley [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value                 $ 1,700,000          
Officers Compensation                 $ 348,000          
Options, Granted                 750,000          
Steven A. Shallcross [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value                       1,900,000    
Options, Granted             900,000              
Deferred Compensation Arrangement with Individual, Compensation Expense     $ 346,500       $ 315,000              
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage             75.00%              
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent             50.00%              
Intrexon [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Research and Development Expense                           $ 7,800,000
Milestone Payment   27,000,000                        
Stock Issued During Period, Shares, Acquisitions                           3,552,210
Prepaid Expense and Other Assets, Current     $ 2,500,000             $ 2,500,000 $ 2,500,000      
Shares Issued, Price Per Share                           $ 0.001
Milestone Payment upon First Dosing   $ 2,000,000                        
Intrexon [Member] | Minimum [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Royalty Revenue, Total                       100,000,000    
Intrexon [Member] | Maximum [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Royalty Revenue, Total                       $ 750,000,000    
Prev Abr Llc [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Additional Cash Payment for License Agreement                           $ 235,000
Unregistered Shares Issued to License Agreement                           625,000
Additional Consideration Payable                           50% in cash and 50% in our stock
Options To Be Received Common Stock Shares                       655,321    
Cedars-Sinai Medical Center [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Common stock Outstanding Percentage     11.50%             11.50% 11.50%      
Office Space In Ann Arbor [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Operating Lease Leasing Term                           extend the term of the lease to December 31, 2016,
Operating Leases, Future Minimum Payments Due, Next Twelve Months                           $ 40,000
Office Space In Rockville [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Operating Lease Leasing Term                           sixty-six month operating lease that may be renewed for one additional term of five years
Operating Annual Lease Payments                           $ 142,172
December 31, 2014 [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Operating Leases, Future Minimum Payments Due, Next Twelve Months                           50,000
December 31, 2015 [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Operating Leases, Future Minimum Payments Due, Next Twelve Months                           25,000
Phase I Clinical Trials [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Milestone Payment                           50,000
Phase III Clinical Trials [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Milestone Payment                           100,000
NDA Submission In US [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Milestone Payment                           250,000
European Medicines Agency Approval [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Milestone Payment                           100,000
Regulatory Approval In Asian Country [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Milestone Payment                           $ 100,000
IND Milestone Event [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Registration Payment Arrangement, Settlement Alternatives                           The Company also agreed upon the filing of an IND application with the FDA for a Synthetic Product, or alternatively the filing of the first equivalent regulatory filing with a foreign regulatory agency (both as applicable, the IND Milestone Event), to pay Intrexon either (i) $2.0 million in cash, or (ii) that number of shares of Common Stock (the IND Milestone Shares) having a fair market value equaling $2.0 million where such fair market value is determined using published market data of the share price for Common Stock at the close of market on the business day immediately preceding the date of public announcement of attainment of the IND Milestone Event.
Approval Milestone Event [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Registration Payment Arrangement, Settlement Alternatives                           Upon the first to occur of either first commercial sale of a Synthetic Product in a country or the granting of the regulatory approval of that Synthetic Product (both as applicable, the Approval Milestone Event), the Company agreed to pay to Intrexon either (i) $3.0 million in cash, or (ii) that number of shares of Common Stock (the Approval Milestone Shares) having a fair market value equaling $3.0 million where such fair market value is determined using published market data of the share price for Common Stock at the close of market on the business day immediately preceding the date of public announcement of attainment of the Approval Milestone Event.
Field Expansion Fee [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Registration Payment Arrangement, Settlement Alternatives                           The Field Expansion Fee must be paid completely in either Common Stock or cash, and will comprise either (i) $2.0 million in cash for each target in excess of three total that the Company elects, or (ii) that number of shares of Common Stock (the Field Expansion Fee Shares) having a fair market value equaling $2.0 million for each such target that the Company elects in excess of three where such fair market value is determined using published market data establishing the volume-weighted average price for a share of Common Stock over the 30 day period immediately preceding the date of the Field Expansion Fee Closing
First Year [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Research Agreement Fixed Fee     $ 303,287             $ 303,287 $ 303,287      
Second Year [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Research Agreement Fixed Fee     316,438             316,438 316,438      
Third Year [Member]                            
License, Collaborative and Employment Agreements and Commitments [Line Items]                            
Research Agreement Fixed Fee     $ 328,758             $ 328,758 $ 328,758